Season 22
Episodes
Episode 1
Luke Wilson, Julie Chen, Lee BriceEpisode 2
Kristen Wiig, Sen. Elizabeth Warren, The New PornographersEpisode 3
Steve Buscemi, Indy Car Season Champ, Alt-JEpisode 4
Tina Fey, Moody McCarthy, Kevin DrewEpisode 5
Bill Maher, Henrik Lundqvist, SpoonEpisode 6
Michael Strahan, Richard Branson, InterpolEpisode 7
Dr. Phil, Katharine McPhee, Death from Above 1979, Ray BensonEpisode 8
Jason Bateman, Billy Eichner, Ryan AdamsEpisode 9
Mindy Kaling, Jake Johannsen, Maddie & TaeEpisode 10
Mark Harmon, "Jungle" Jack HannaEpisode 11
Denzel Washington, Lenny KravitzEpisode 12
Kelly Ripa, Jim Gaffigan, Paloma FaithEpisode 13
Jerry Seinfeld, Michael Jackson ONEEpisode 14
Ted Danson, Andrew NorelliEpisode 15
Neil Patrick Harris, Jamie Oliver, Aretha FranklinEpisode 16
John Oliver, Maggie Q, BleachersEpisode 17
Bill O'Reilly, Cristin MiliotiEpisode 18
Johnny Galecki, Andre Benjamin, Delta SpiritEpisode 19
Mariska Hargitay, Simon Amstell, Kandace SpringsEpisode 20
Aziz Ansari, Tom DreesenEpisode 21
Robert Downey Jr., Sarah Paulson, LizzoEpisode 22
Anderson Cooper, Gina Rodriguez, Hatsune MikuEpisode 23
Robert Duvall, Elle Fanning, Rival SonsEpisode 24
Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena PresleyTV host Chelsea Handler; comics Keegan-Michael Key and Jordan Peele; Angaleena Presley performs.
Episode 25
Russell Brand, Dave Grohl, Foo FightersEpisode 26
Michael Keaton, Foo FightersEpisode 27
Bill Murray, Foo FightersEpisode 28
Tom Selleck, Jenny Slate, Foo FightersEpisode 29
Jessica Chastain, Lenny Marcus, Foo FightersEpisode 30
Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee LewisEpisode 31
Taylor Swift, Tom MisonEpisode 32
Jim Carrey, David TennantEpisode 33
Brian Williams, Perfume GeniusEpisode 34
Keith Olbermann, Brian Regan, Run the JewelsEpisode 35
Martin Short, Father John MistyEpisode 36
Jennifer Lopez, Rob Riggle, KimbraEpisode 37
Whoopi Goldberg, Jimmy Page, MapeiEpisode 38
Amy Schumer, Jeff CaldwellEpisode 39
Katie Holmes, Alex ZanardiEpisode 40
Steve Carell, Martha Stewart, OK GoEpisode 41
Jennifer Lawrence, Boris JohnsonEpisode 42
Jon Stewart, Shawn MendesEpisode 43
Kristin Chenoweth; Chris YoungActress Kristin Chenoweth; Chris Young performs.
Episode 44
Jason Sudeikis, Allison Janney, Damien RiceEpisode 45
Stupid Pet Tricks, Charlie Day, Hiss Golden MessengerEpisode 46
Regis Philbin, Hundred WatersEpisode 47
Edward Norton, Jessye NormanEpisode 48
Norman Lear, TV on the RadioEpisode 49
Seth Rogen, Amy SedarisEpisode 50
Emily Blunt, Adam Resnick, Wu-Tang ClanEpisode 51
Jake Gyllenhaal, Dr. John P. Holdren, Nico & VinzEpisode 52
Joaquin Phoenix, Cristela Alonzo, Al GreenEpisode 53
Ben Stiller, Olivia Munn, LaLa BrooksEpisode 54
Meryl Streep, Rebel Wilson, J. ColeEpisode 55
Chris Rock, StingEpisode 56
Jamie Foxx, Robert Klein, Dan PennEpisode 57
Emma Stone Top, Marcus Mariota, Bob SegerEpisode 58
New Holiday Toys, Anna Kendrick, Charli XCXEpisode 59
Tom Brokaw, Will Nelson & Billy Joe ShaverEpisode 60
Rosie O’Donnel,l Jeff AltmanEpisode 61
Jay Thomas, Josh Brolin, Darlene LoveThe final Christmas episode. Jay Thomas drops by to once again tell "The best talk show story, ever", then he and David try to knock the meatball off the Christmas tree in the Late Show Quarterback Challenge. An interview with Josh Brolin. The show wraps up with Darlene Love's last Late Show performance of Christmas (Baby Please Come Home).
Episode 62
Kathy Griffin, David Oyelowo, Lera LynnEpisode 63
Ethan Hawke, Allison Williams, Parquet CourtsEpisode 64
Julianne Moore, Catfish & the BottlemenEpisode 65
Donald Trump, Chelsea Peretti, FoxygenEpisode 66
Michael Somerville, Nicole AtkinsEpisode 67
Gordon Ramsay, Adam Devine, St. Paul and the Broken BonesEpisode 68
Anderson Cooper, Shovels & RopeEpisode 69
Amanda Peet, Ryn WeaverEpisode 70
Larry David, Dan Patrick, Sleater-KinneyEpisode 71
Urban Meyer, Johnny Beehner, Ella HendersonEpisode 72
Louis CK, Nicolle Wallace, the Lone BellowEpisode 73
Andrew Luck, Oscar Isaac, DrengeEpisode 74
Viola Davis, Ben Schwartz, Marty StuartEpisode 75
John Oliver, Mayim Bialik, Death Cab for CutieEpisode 76
Aziz Ansari, Brian Kiley, Ben HowardEpisode 77
Jack Hanna, Sharon Jones and the Dap-KingsEpisode 78
Dr. Phil McGraw, Robin Tunney, Diana KrallEpisode 79
Ryan Reynolds, Dierks BentleyEpisode 80
Martin Short, Bettye LavetteEpisode 81
Sienna Miller, Andy Kindler, Bob MouldEpisode 82
Steve Carell, Dr. Cornel WestEpisode 83
Courtney Love, Chris Elliott, Rhiannon GiddensEpisode 84
Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama BearEpisode 85
Tom Hanks, Sturgill SimpsonEpisode 86
Bill Hader, Pat McGann, Shakey GravesEpisode 87
Matthew Perry, Adam Scott, Kishi BashiEpisode 88
Dakota Johnson, David Tochinskiy, Twin ShadowEpisode 89
Will Smith, GrizfolkEpisode 90
Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky EkkoEpisode 91
Kid Scientists, Sean Hayes, Judah & the LionEpisode 92
Helen Mirren, the 2015 Daytona 500 winner, Steve EarleEpisode 93
Matthew Broderick, Ellie Kemper, JD McPhersonEpisode 94
Julianna Margulies, Eric Ripert, Glass AnimalsEpisode 95
Kevin Spacey, Lily James, Alabama ShakesEpisode 96
Patricia Arquette, Will ButlerEpisode 97
Kelsey Grammer, Stevie WonderEpisode 98
Lena Dunham, Bobby Cannavale, Andy Kim with Kevin DrewEpisode 99
Kevin Bacon, Jimmie Walker, Airborne Toxic EventEpisode 100
Shailene Woodley, Dr. Cornel West, Matthew E. WhiteEpisode 101
Will Ferrell, Glen HansardEpisode 102
Norm MacDonald, Theo JamesEpisode 103
Ben Stiller, Tove LoEpisode 104
Bill O'Reilly, Aubrey PlazaEpisode 105
James Franco, Jake Johannsen, Action BronsonEpisode 106
Neil Patrick Harris, Charlie Cox, the SuffersEpisode 107
David Duchovny, Josh Gad, HoundmouthEpisode 108
Sen. Al Franken, Billy Eichner, David SanbornEpisode 109
Kelly Ripa, Aasif Mandvi, Fat White FamilyEpisode 110
Mike Myers, Nick Griffin, BanksEpisode 111
Sarah Jessica Parker, Julie Chen, Asleep at the WheelEpisode 112
Billy Crystal, Chris Russo, Chris StapletonEpisode 113
Michael J. Fox, Iron & Wine, Ben BridwellEpisode 114
Kevin James, Tom Dreesen, Tracy Chapman
Episode 115
Alec Baldwin, John MayerEpisode 116
John Travolta, Amy Schumer, the WaterboysEpisode 117
Piedmont Bird Callers, Paul RuddEpisode 118
Bruce Willis, DawesEpisode 119
Robert Downey Jr., Chris Russo, Elvis CostelloEpisode 120
Jerry Seinfeld, Jason Isbell & Amanda ShiresEpisode 121
Scarlett Johansson, John Mellencamp, Todd RundgrenEpisode 122
Michael Keaton, Future IslandsEpisode 123
Jack Hanna, John PopperEpisode 124
First Lady Michelle Obama Hootie and the BlowfishEpisode 125
Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'ConnorEpisode 126
President Barack Obama, Will Ferrell, the Avett Brothers, Brandi CarlileEpisode 127
Reese Witherspoon, Nathan Lane, Mumford & SonsEpisode 128
Martin Short, Norah JonesEpisode 129
Tina Fey, First Aid KitEpisode 130
Ray Romano, Brian Regan, Dave Matthews BandEpisode 131
Howard Stern, Don RicklesEpisode 132
Bill Clinton, Adam SandlerEpisode 133
Julia Roberts, Paul Shaffer, Ryan AdamsEpisode 134
Al Pacino, George Clooney, Tom WaitsEpisode 135
Oprah Winfrey, Norm MacdonaldEpisode 136
Tom Hanks, Eddie VedderEpisode 137
Bill Murray, Bob DylanEpisode 138
The Final Late Show with David Letterman6,028th broadcast
Episode 149
Episode 149The final episode includes surprises, memorable highlights and the last Top Ten List.
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